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Collectively, our in vitro measurements suggest that the improvements in LaccID result from a combination of higher thermal stability and increased turnover at physiological pH (7 to 7.4) compared to LacAnc100

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This receptor upregulation combines with BPC-157's activation of the Src-Caveolin-1-eNOS signaling cascade, which increases nitric oxide production by 1.35-fold and proves essential for the peptide's pro-migratory effects on endothelial cells

Santo L, Kang K

Thus, specific targeting of IGF-1R signaling post development may prove to be the best approach to achieve the benefits of low growth signals on healthspan and aging, without the potential unwanted side effects of combined adult-onset GH/IGF-1 deficiency